↓ Skip to main content

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase

Overview of attention for article published in Malaria Journal, April 2008
Altmetric Badge

Mentioned by

f1000
1 research highlight platform

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
56 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
Published in
Malaria Journal, April 2008
DOI 10.1186/1475-2875-7-72
Pubmed ID
Authors

Vivian N Hawkins, Alyson Auliff, Surendra Kumar Prajapati, Kanchana Rungsihirunrat, Hapuarachchige C Hapuarachchi, Amanda Maestre, Michael T O'Neil, Qin Cheng, Hema Joshi, Kesara Na-Bangchang, Carol Hopkins Sibley

Abstract

In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. Recent work has demonstrated that pyrimethamine-resistance conferring mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) have arisen rarely de novo, but spread widely in Asia and Africa. The origin and spread of mutations in Plasmodium vivax dhfr were assessed by constructing haplotypes based on sequencing dhfr and its flanking regions.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United Kingdom 1 2%
Unknown 54 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 21%
Student > Master 10 18%
Student > Ph. D. Student 8 14%
Student > Bachelor 4 7%
Other 3 5%
Other 7 13%
Unknown 12 21%
Readers by discipline Count As %
Medicine and Dentistry 17 30%
Biochemistry, Genetics and Molecular Biology 9 16%
Agricultural and Biological Sciences 8 14%
Social Sciences 3 5%
Immunology and Microbiology 3 5%
Other 4 7%
Unknown 12 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2008.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from Malaria Journal
#4,449
of 5,538 outputs
Outputs of similar age
#67,486
of 79,839 outputs
Outputs of similar age from Malaria Journal
#16
of 21 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,538 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 79,839 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.