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A rapid and sensitive bioassay to measure bone morphogenetic protein activity

Overview of attention for article published in BMC Molecular and Cell Biology, September 2007
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Title
A rapid and sensitive bioassay to measure bone morphogenetic protein activity
Published in
BMC Molecular and Cell Biology, September 2007
DOI 10.1186/1471-2121-8-41
Pubmed ID
Authors

Lior Zilberberg, Peter ten Dijke, Lynn Y Sakai, Daniel B Rifkin

Abstract

Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily and were originally identified as proteins that induce ectopic bone formation. BMPs were shown subsequently to be involved in several biological processes during development and in adult tissues through the regulation of the growth, differentiation and apoptosis of various cell types. An alkaline phosphatase (ALP)-based assay is the most widely used assay to evaluate BMP activity. However, the ALP assay is not rapid and not sensitive enough to measure BMP activity at physiological concentrations. In this paper, we describe a highly sensitive, rapid, and specific cell-based assay for the quantification of BMP activity.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Gambia 1 1%
Australia 1 1%
United Kingdom 1 1%
Japan 1 1%
Unknown 94 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 30%
Researcher 23 23%
Student > Doctoral Student 8 8%
Student > Master 7 7%
Student > Bachelor 6 6%
Other 19 19%
Unknown 6 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 40%
Biochemistry, Genetics and Molecular Biology 22 22%
Medicine and Dentistry 8 8%
Engineering 6 6%
Chemistry 5 5%
Other 10 10%
Unknown 8 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2007.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from BMC Molecular and Cell Biology
#778
of 1,233 outputs
Outputs of similar age
#71,935
of 83,184 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#20
of 22 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,184 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.