Title |
The PowerAtlas: a power and sample size atlas for microarray experimental design and research
|
---|---|
Published in |
BMC Bioinformatics, February 2006
|
DOI | 10.1186/1471-2105-7-84 |
Pubmed ID | |
Authors |
Grier P Page, Jode W Edwards, Gary L Gadbury, Prashanth Yelisetti, Jelai Wang, Prinal Trivedi, David B Allison |
Abstract |
Microarrays permit biologists to simultaneously measure the mRNA abundance of thousands of genes. An important issue facing investigators planning microarray experiments is how to estimate the sample size required for good statistical power. What is the projected sample size or number of replicate chips needed to address the multiple hypotheses with acceptable accuracy? Statistical methods exist for calculating power based upon a single hypothesis, using estimates of the variability in data from pilot studies. There is, however, a need for methods to estimate power and/or required sample sizes in situations where multiple hypotheses are being tested, such as in microarray experiments. In addition, investigators frequently do not have pilot data to estimate the sample sizes required for microarray studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 4% |
United Kingdom | 2 | 2% |
France | 2 | 2% |
Malaysia | 1 | 1% |
Norway | 1 | 1% |
Germany | 1 | 1% |
Switzerland | 1 | 1% |
Italy | 1 | 1% |
Argentina | 1 | 1% |
Other | 1 | 1% |
Unknown | 83 | 85% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 32 | 33% |
Student > Ph. D. Student | 27 | 28% |
Professor > Associate Professor | 8 | 8% |
Student > Master | 7 | 7% |
Other | 6 | 6% |
Other | 13 | 13% |
Unknown | 5 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 44 | 45% |
Medicine and Dentistry | 16 | 16% |
Biochemistry, Genetics and Molecular Biology | 9 | 9% |
Mathematics | 7 | 7% |
Computer Science | 2 | 2% |
Other | 13 | 13% |
Unknown | 7 | 7% |