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Mining gene networks with application to GAW15 Problem 1

Overview of attention for article published in BMC Proceedings, December 2007
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Title
Mining gene networks with application to GAW15 Problem 1
Published in
BMC Proceedings, December 2007
DOI 10.1186/1753-6561-1-s1-s52
Pubmed ID
Authors

Jing Hua Zhao, Jian'an Luan, M Fazil Baksh, Qihua Tan

Abstract

The Genetic Analysis Workshop 15 (GAW15) Problem 1 contained baseline expression levels of 8793 genes in immortalized B cells from 194 individuals in 14 Centre d'Etude du Polymorphisme Humain (CEPH) Utah pedigrees. Previous analysis of the data showed linkage and association and evidence of substantial individual variations. In particular, correlation was examined on expression levels of 31 genes and 25 target genes corresponding to two master regulatory regions. In this analysis, we apply Bayesian network analysis to gain further insight into these findings. We identify strong dependences and therefore provide additional insight into the underlying relationships between the genes involved. More generally, the approach is expected to be applicable for integrated analysis of genes on biological pathways.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 17%
Unknown 5 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Professor > Associate Professor 1 17%
Student > Master 1 17%
Unknown 2 33%
Readers by discipline Count As %
Business, Management and Accounting 1 17%
Computer Science 1 17%
Agricultural and Biological Sciences 1 17%
Medicine and Dentistry 1 17%
Unknown 2 33%