Early Phase Trial to Find Maximal Tolerated Dose (MTD) - 3+3, CRM, and BOIN Designs
On Biostatistics and Clinical Trials,
In early-phase clinical trials, determining the dose range and therapeutic window is critical. The purpose of the early-phase…
In early-phase clinical trials, determining the dose range and therapeutic window is critical. The purpose of the early-phase…
The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated…