Report for: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

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Title	Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
Published in	Respiratory Research, August 2009
DOI	10.1186/1465-9921-10-73
Pubmed ID	19671143
Authors	Mateusz Siedlinski, Dirkje S Postma, Jolanda MA Boer, Gerrit van der Steege, Jan P Schouten, Henriette A Smit, H Marike Boezen
Abstract	The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induced emphysema. We assessed the impact of Single Nucleotide Polymorphisms (SNPs) in both genes on the level and longitudinal course of Forced Expiratory Volume in 1 second (FEV1) in the general population.

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Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United Kingdom	1	3%
Unknown	35	97%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	10	28%
Researcher	8	22%
Student > Doctoral Student	4	11%
Professor	3	8%
Other	2	6%
Other	7	19%
Unknown	2	6%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	11	31%
Medicine and Dentistry	9	25%
Biochemistry, Genetics and Molecular Biology	6	17%
Pharmacology, Toxicology and Pharmaceutical Science	2	6%
Computer Science	2	6%
Other	3	8%
Unknown	3	8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2009.

All research outputs

#12,350,034

of 18,787,703 outputs

Outputs from Respiratory Research

#1,672

of 2,349 outputs

Outputs of similar age

#143,142

of 234,006 outputs

Outputs of similar age from Respiratory Research

#62

of 70 outputs

Altmetric has tracked 18,787,703 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.

So far Altmetric has tracked 2,349 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.

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We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.

Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

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Geographical breakdown

Demographic breakdown

Attention Score in Context