Title |
Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
|
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Published in |
Respiratory Research, August 2009
|
DOI | 10.1186/1465-9921-10-73 |
Pubmed ID | |
Authors |
Mateusz Siedlinski, Dirkje S Postma, Jolanda MA Boer, Gerrit van der Steege, Jan P Schouten, Henriette A Smit, H Marike Boezen |
Abstract |
The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induced emphysema. We assessed the impact of Single Nucleotide Polymorphisms (SNPs) in both genes on the level and longitudinal course of Forced Expiratory Volume in 1 second (FEV1) in the general population. |
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Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 23% |
Student > Doctoral Student | 4 | 10% |
Professor | 3 | 8% |
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