Title |
Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone
|
---|---|
Published in |
Journal of Orthopaedic Surgery and Research, November 2010
|
DOI | 10.1186/1749-799x-5-85 |
Pubmed ID | |
Authors |
Yoshihiro Matsumoto, Yuko Okada, Jun-ichi Fukushi, Satoshi Kamura, Toshifumi Fujiwara, Keiichiro Iida, Mihoko Koga, Shuichi Matsuda, Katsumi Harimaya, Akio Sakamoto, Yukihide Iwamoto |
Abstract |
Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumor cells, while monocyte-like cells and MNCs are reactive osteoclast precursor cells (OPCs) and osteoclasts (OCs), respectively. In this study, we investigated the pathogenesis of osteoclastic bone destruction in GCTs by focusing on the role of the vascular endothelial growth factor (VEGF)-Flt-1 (type-1 VEGF receptor)-focal adhesion kinase (FAK) pathway. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 8% |
Italy | 1 | 8% |
Unknown | 11 | 85% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 38% |
Student > Ph. D. Student | 3 | 23% |
Student > Bachelor | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Professor > Associate Professor | 1 | 8% |
Other | 0 | 0% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 69% |
Immunology and Microbiology | 1 | 8% |
Engineering | 1 | 8% |
Unknown | 2 | 15% |