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Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone

Overview of attention for article published in Journal of Orthopaedic Surgery and Research, November 2010
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Title
Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone
Published in
Journal of Orthopaedic Surgery and Research, November 2010
DOI 10.1186/1749-799x-5-85
Pubmed ID
Authors

Yoshihiro Matsumoto, Yuko Okada, Jun-ichi Fukushi, Satoshi Kamura, Toshifumi Fujiwara, Keiichiro Iida, Mihoko Koga, Shuichi Matsuda, Katsumi Harimaya, Akio Sakamoto, Yukihide Iwamoto

Abstract

Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumor cells, while monocyte-like cells and MNCs are reactive osteoclast precursor cells (OPCs) and osteoclasts (OCs), respectively. In this study, we investigated the pathogenesis of osteoclastic bone destruction in GCTs by focusing on the role of the vascular endothelial growth factor (VEGF)-Flt-1 (type-1 VEGF receptor)-focal adhesion kinase (FAK) pathway.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 8%
Italy 1 8%
Unknown 11 85%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 38%
Student > Ph. D. Student 3 23%
Student > Bachelor 1 8%
Student > Doctoral Student 1 8%
Professor > Associate Professor 1 8%
Other 0 0%
Unknown 2 15%
Readers by discipline Count As %
Medicine and Dentistry 9 69%
Immunology and Microbiology 1 8%
Engineering 1 8%
Unknown 2 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2011.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#776
of 1,627 outputs
Outputs of similar age
#89,591
of 111,011 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#2
of 4 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,627 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,011 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.