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The ribosomal protein genes and Minute loci of Drosophila melanogaster

Overview of attention for article published in Genome Biology (Online Edition), January 2007
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Title
The ribosomal protein genes and Minute loci of Drosophila melanogaster
Published in
Genome Biology (Online Edition), January 2007
DOI 10.1186/gb-2007-8-10-r216
Pubmed ID
Authors

Steven J Marygold, John Roote, Gunter Reuter, Andrew Lambertsson, Michael Ashburner, Gillian H Millburn, Paul M Harrison, Zhan Yu, Naoya Kenmochi, Thomas C Kaufman, Sally J Leevers, Kevin R Cook

Abstract

Mutations in genes encoding ribosomal proteins (RPs) have been shown to cause an array of cellular and developmental defects in a variety of organisms. In Drosophila melanogaster, disruption of RP genes can result in the 'Minute' syndrome of dominant, haploinsufficient phenotypes, which include prolonged development, short and thin bristles, and poor fertility and viability. While more than 50 Minute loci have been defined genetically, only 15 have so far been characterized molecularly and shown to correspond to RP genes. We combined bioinformatic and genetic approaches to conduct a systematic analysis of the relationship between RP genes and Minute loci. First, we identified 88 genes encoding 79 different cytoplasmic RPs (CRPs) and 75 genes encoding distinct mitochondrial RPs (MRPs). Interestingly, nine CRP genes are present as duplicates and, while all appear to be functional, one member of each gene pair has relatively limited expression. Next, we defined 65 discrete Minute loci by genetic criteria. Of these, 64 correspond to, or very likely correspond to, CRP genes; the single non-CRP-encoding Minute gene encodes a translation initiation factor subunit. Significantly, MRP genes and more than 20 CRP genes do not correspond to Minute loci. This work answers a longstanding question about the molecular nature of Minute loci and suggests that Minute phenotypes arise from suboptimal protein synthesis resulting from reduced levels of cytoribosomes. Furthermore, by identifying the majority of haplolethal and haplosterile loci at the molecular level, our data will directly benefit efforts to attain complete deletion coverage of the D. melanogaster genome.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Switzerland 2 <1%
Sweden 1 <1%
United Kingdom 1 <1%
Spain 1 <1%
Germany 1 <1%
Unknown 236 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 25%
Researcher 45 18%
Student > Bachelor 31 13%
Student > Master 29 12%
Student > Doctoral Student 14 6%
Other 33 13%
Unknown 33 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 112 45%
Biochemistry, Genetics and Molecular Biology 65 26%
Medicine and Dentistry 8 3%
Environmental Science 4 2%
Neuroscience 4 2%
Other 17 7%
Unknown 37 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2021.
All research outputs
#14,916,248
of 18,623,929 outputs
Outputs from Genome Biology (Online Edition)
#3,575
of 3,732 outputs
Outputs of similar age
#250,819
of 358,218 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 1 outputs
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