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Metabonomics adds a new dimension to fragile X syndrome

Overview of attention for article published in Genome Medicine, December 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

blogs
1 blog
twitter
2 X users

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
25 Mendeley
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Title
Metabonomics adds a new dimension to fragile X syndrome
Published in
Genome Medicine, December 2011
DOI 10.1186/gm296
Pubmed ID
Authors

Inge Heulens, Sien Braat, R Frank Kooy

Abstract

Fragile X syndrome is the most common cause of inherited intellectual disability, but the underlying pathophysiology is complex and effective treatments are lacking. In a recent study of fragile X mental retardation 1 (Fmr1) knockout mice, the metabolic profile of the fragile X brain was determined using proton high-resolution magic angle spinning nuclear magnetic resonance spectroscopy. This analysis revealed deficiencies in four metabolic categories: neurotransmission, osmoregulation, energy metabolism and oxidative stress response. Abnormalities in the metabolic phenotype were linked to the fragile X mental retardation protein using an integrated metabolome and interactome mapping approach, allowing a global picture of the disorder to emerge.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 32%
Student > Bachelor 3 12%
Researcher 3 12%
Student > Doctoral Student 2 8%
Student > Master 2 8%
Other 4 16%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 36%
Biochemistry, Genetics and Molecular Biology 4 16%
Neuroscience 2 8%
Nursing and Health Professions 1 4%
Medicine and Dentistry 1 4%
Other 1 4%
Unknown 7 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2012.
All research outputs
#3,608,341
of 25,373,627 outputs
Outputs from Genome Medicine
#778
of 1,585 outputs
Outputs of similar age
#27,417
of 249,540 outputs
Outputs of similar age from Genome Medicine
#6
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,585 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.8. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.