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Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)

Overview of attention for article published in Journal of Neuroinflammation, January 2012
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Title
Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)
Published in
Journal of Neuroinflammation, January 2012
DOI 10.1186/1742-2094-9-1
Pubmed ID
Authors

Pascal F Durrenberger, Anna Ettorre, Fatemah Kamel, Louise V Webb, Malcolm Sim, Richard S Nicholas, Omar Malik, Richard Reynolds, Rosemary J Boyton, Daniel M Altmann

Abstract

Pathogenic or regulatory effects of natural killer (NK) cells are implicated in many autoimmune diseases, but evidence in multiple sclerosis (MS) and its murine models remains equivocal. In an effort to illuminate this, we have here analysed expression of the prototypic NK cell marker, NCR1 (natural cytotoxicity triggering receptor; NKp46; CD335), an activating receptor expressed by virtually all NK cells and therefore considered a pan-marker for NK cells. The only definitive ligand of NCR1 is influenza haemagglutinin, though there are believed to be others. In this study, we investigated whether there were differences in NCR1+ cells in the peripheral blood of MS patients and whether NCR1+ cells are present in white matter lesions.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 4%
Unknown 52 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 24%
Researcher 10 19%
Student > Master 8 15%
Student > Bachelor 6 11%
Other 3 6%
Other 7 13%
Unknown 7 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 24%
Medicine and Dentistry 10 19%
Immunology and Microbiology 6 11%
Neuroscience 6 11%
Biochemistry, Genetics and Molecular Biology 5 9%
Other 6 11%
Unknown 8 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2012.
All research outputs
#15,241,259
of 22,661,413 outputs
Outputs from Journal of Neuroinflammation
#1,727
of 2,604 outputs
Outputs of similar age
#163,250
of 244,210 outputs
Outputs of similar age from Journal of Neuroinflammation
#16
of 31 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,604 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,210 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.