Title |
Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)
|
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Published in |
Journal of Neuroinflammation, January 2012
|
DOI | 10.1186/1742-2094-9-1 |
Pubmed ID | |
Authors |
Pascal F Durrenberger, Anna Ettorre, Fatemah Kamel, Louise V Webb, Malcolm Sim, Richard S Nicholas, Omar Malik, Richard Reynolds, Rosemary J Boyton, Daniel M Altmann |
Abstract |
Pathogenic or regulatory effects of natural killer (NK) cells are implicated in many autoimmune diseases, but evidence in multiple sclerosis (MS) and its murine models remains equivocal. In an effort to illuminate this, we have here analysed expression of the prototypic NK cell marker, NCR1 (natural cytotoxicity triggering receptor; NKp46; CD335), an activating receptor expressed by virtually all NK cells and therefore considered a pan-marker for NK cells. The only definitive ligand of NCR1 is influenza haemagglutinin, though there are believed to be others. In this study, we investigated whether there were differences in NCR1+ cells in the peripheral blood of MS patients and whether NCR1+ cells are present in white matter lesions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | 4% |
Unknown | 52 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 24% |
Researcher | 10 | 19% |
Student > Master | 8 | 15% |
Student > Bachelor | 6 | 11% |
Other | 3 | 6% |
Other | 7 | 13% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 24% |
Medicine and Dentistry | 10 | 19% |
Immunology and Microbiology | 6 | 11% |
Neuroscience | 6 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Other | 6 | 11% |
Unknown | 8 | 15% |