Title |
Mechanisms of allergen‐specific immunotherapy
|
---|---|
Published in |
Clinical and Translational Allergy, January 2012
|
DOI | 10.1186/2045-7022-2-2 |
Pubmed ID | |
Authors |
Hiroyuki Fujita, Michael B Soyka, Mübeccel Akdis, Cezmi A Akdis |
Abstract |
Allergen-specific immunotherapy (allergen-SIT) is a potentially curative treatment approach in allergic diseases. It has been used for almost 100 years as a desensitizing therapy. The induction of peripheral T cell tolerance and promotion of the formation of regulatory T-cells are key mechanisms in allergen-SIT. Both FOXP3+CD4+CD25+ regulatory T (Treg) cells and inducible IL-10- and TGF-β-producing type 1 Treg (Tr1) cells may prevent the development of allergic diseases and play a role in successful allergen-SIT and healthy immune response via several mechanisms. The mechanisms of suppression of different pro-inflammatory cells, such as eosinophils, mast cells and basophils and the development of allergen tolerance also directly or indirectly involves Treg cells. Furthermore, the formation of non-inflammatory antibodies particularly IgG4 is induced by IL-10. Knowledge of these molecular basis is crucial in the understanding the regulation of immune responses and their possible therapeutic targets in allergic diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Taiwan | 1 | 13% |
Argentina | 1 | 13% |
United States | 1 | 13% |
United Kingdom | 1 | 13% |
France | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 75% |
Scientists | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 1% |
United Kingdom | 1 | <1% |
Chile | 1 | <1% |
India | 1 | <1% |
Unknown | 177 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 35 | 19% |
Student > Ph. D. Student | 31 | 17% |
Student > Bachelor | 27 | 15% |
Researcher | 22 | 12% |
Other | 12 | 7% |
Other | 20 | 11% |
Unknown | 35 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 43 | 24% |
Agricultural and Biological Sciences | 40 | 22% |
Immunology and Microbiology | 19 | 10% |
Biochemistry, Genetics and Molecular Biology | 15 | 8% |
Engineering | 9 | 5% |
Other | 20 | 11% |
Unknown | 36 | 20% |