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Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control

Overview of attention for article published in BMC Systems Biology, January 2012
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1 tweeter

Citations

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43 Mendeley
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Title
Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control
Published in
BMC Systems Biology, January 2012
DOI 10.1186/1752-0509-6-2
Pubmed ID
Authors

Kevin M D'Auria, Gina M Donato, Mary C Gray, Glynis L Kolling, Cirle A Warren, Lauren M Cave, Michael D Solga, Joanne A Lannigan, Jason A Papin, Erik L Hewlett

Abstract

Toxins A and B (TcdA and TcdB) are Clostridium difficile's principal virulence factors, yet the pathways by which they lead to inflammation and severe diarrhea remain unclear. Also, the relative role of either toxin during infection and the differences in their effects across cell lines is still poorly understood. To better understand their effects in a susceptible cell line, we analyzed the transciptome-wide gene expression response of human ileocecal epithelial cells (HCT-8) after 2, 6, and 24 hr of toxin exposure.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
France 1 2%
Germany 1 2%
Unknown 39 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Student > Bachelor 6 14%
Researcher 5 12%
Professor 4 9%
Professor > Associate Professor 4 9%
Other 8 19%
Unknown 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 26%
Biochemistry, Genetics and Molecular Biology 7 16%
Immunology and Microbiology 5 12%
Engineering 4 9%
Arts and Humanities 1 2%
Other 7 16%
Unknown 8 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2012.
All research outputs
#15,055,021
of 18,796,975 outputs
Outputs from BMC Systems Biology
#816
of 1,127 outputs
Outputs of similar age
#180,419
of 234,923 outputs
Outputs of similar age from BMC Systems Biology
#81
of 106 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,127 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,923 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.