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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Overview of attention for article published in Molecular Neurodegeneration, December 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

blogs
1 blog
twitter
6 X users

Citations

dimensions_citation
93 Dimensions

Readers on

mendeley
98 Mendeley
citeulike
1 CiteULike
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Title
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Published in
Molecular Neurodegeneration, December 2011
DOI 10.1186/1750-1326-6-88
Pubmed ID
Authors

Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar

Abstract

The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD). Clinical development of BACE1 inhibitors is being intensely pursued. However, little is known about the physiological functions of BACE1, and the possibility exists that BACE1 inhibition may cause mechanism-based side effects. Indeed, BACE1-/- mice exhibit a complex neurological phenotype. Interestingly, BACE1 co-localizes with presynaptic neuronal markers, indicating a role in axons and/or terminals. Moreover, recent studies suggest axon guidance molecules are potential BACE1 substrates. Here, we used a genetic approach to investigate the function of BACE1 in axon guidance of olfactory sensory neurons (OSNs), a well-studied model of axon targeting in vivo.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Canada 1 1%
Germany 1 1%
Spain 1 1%
Peru 1 1%
Unknown 91 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 23%
Researcher 20 20%
Student > Bachelor 13 13%
Student > Master 10 10%
Professor 5 5%
Other 17 17%
Unknown 10 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 37%
Neuroscience 25 26%
Biochemistry, Genetics and Molecular Biology 9 9%
Medicine and Dentistry 7 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 7 7%
Unknown 12 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2012.
All research outputs
#2,719,124
of 23,577,654 outputs
Outputs from Molecular Neurodegeneration
#356
of 875 outputs
Outputs of similar age
#21,445
of 247,293 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 22 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 875 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.