Title |
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
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Published in |
Molecular Neurodegeneration, December 2011
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DOI | 10.1186/1750-1326-6-88 |
Pubmed ID | |
Authors |
Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar |
Abstract |
The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD). Clinical development of BACE1 inhibitors is being intensely pursued. However, little is known about the physiological functions of BACE1, and the possibility exists that BACE1 inhibition may cause mechanism-based side effects. Indeed, BACE1-/- mice exhibit a complex neurological phenotype. Interestingly, BACE1 co-localizes with presynaptic neuronal markers, indicating a role in axons and/or terminals. Moreover, recent studies suggest axon guidance molecules are potential BACE1 substrates. Here, we used a genetic approach to investigate the function of BACE1 in axon guidance of olfactory sensory neurons (OSNs), a well-studied model of axon targeting in vivo. |
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Geographical breakdown
Country | Count | As % |
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Canada | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 3% |
Canada | 1 | 1% |
Germany | 1 | 1% |
Spain | 1 | 1% |
Peru | 1 | 1% |
Unknown | 91 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 20 | 20% |
Student > Bachelor | 13 | 13% |
Student > Master | 10 | 10% |
Professor | 5 | 5% |
Other | 17 | 17% |
Unknown | 10 | 10% |
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Neuroscience | 25 | 26% |
Biochemistry, Genetics and Molecular Biology | 9 | 9% |
Medicine and Dentistry | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 7 | 7% |
Unknown | 12 | 12% |