Title |
Multiple congenital ocular anomalies in Icelandic horses
|
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Published in |
BMC Veterinary Research, May 2011
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DOI | 10.1186/1746-6148-7-21 |
Pubmed ID | |
Authors |
Lisa S Andersson, Jeanette Axelsson, Richard R Dubielzig, Gabriella Lindgren, Björn Ekesten |
Abstract |
Multiple congenital ocular anomalies (MCOA) syndrome is a hereditary congenital eye defect that was first described in Silver colored Rocky Mountain horses. The mutation causing this disease is located within a defined chromosomal interval, which also contains the gene and mutation that is associated with the Silver coat color (PMEL17, exon 11). Horses that are homozygous for the disease-causing allele have multiple defects (MCOA-phenotype), whilst the heterozygous horses predominantly have cysts of the iris, ciliary body or retina (Cyst-phenotype). It has been argued that these ocular defects are caused by a recent mutation that is restricted to horses that are related to the Rocky Mountain Horse breed. For that reason we have examined another horse breed, the Icelandic horse, which is historically quite divergent from Rocky Mountain horses. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 14% |
Student > Master | 5 | 14% |
Professor | 4 | 11% |
Student > Postgraduate | 4 | 11% |
Other | 4 | 11% |
Other | 7 | 20% |
Unknown | 6 | 17% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 10 | 29% |
Agricultural and Biological Sciences | 9 | 26% |
Medicine and Dentistry | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Unspecified | 1 | 3% |
Other | 0 | 0% |
Unknown | 7 | 20% |