Title |
Policing of gut microbiota by the adaptive immune system
|
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Published in |
BMC Medicine, February 2016
|
DOI | 10.1186/s12916-016-0573-y |
Pubmed ID | |
Authors |
Laurent Dollé, Hao Q. Tran, Lucie Etienne-Mesmin, Benoit Chassaing |
Abstract |
The intestinal microbiota is a large and diverse microbial community that inhabits the intestine, containing about 100 trillion bacteria of 500-1000 distinct species that, collectively, provide benefits to the host. The human gut microbiota composition is determined by a myriad of factors, among them genetic and environmental, including diet and medication. The microbiota contributes to nutrient absorption and maturation of the immune system. As reciprocity, the host immune system plays a central role in shaping the composition and localization of the intestinal microbiota. Secretory immunoglobulins A (sIgAs), component of the adaptive immune system, are important player in the protection of epithelium, and are known to have an important impact on the regulation of microbiota composition. A recent study published in Immunity by Fransen and colleagues aimed to mechanistically decipher the interrelationship between sIgA and microbiota diversity/composition. This commentary will discuss these important new findings, as well as how future therapies can ultimately benefit from such discovery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 5 | 42% |
Spain | 1 | 8% |
Netherlands | 1 | 8% |
Ireland | 1 | 8% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 58% |
Practitioners (doctors, other healthcare professionals) | 4 | 33% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | <1% |
Australia | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 123 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 16% |
Student > Ph. D. Student | 18 | 14% |
Student > Bachelor | 13 | 10% |
Student > Master | 12 | 9% |
Student > Doctoral Student | 8 | 6% |
Other | 26 | 20% |
Unknown | 31 | 24% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 23 | 18% |
Biochemistry, Genetics and Molecular Biology | 20 | 16% |
Medicine and Dentistry | 18 | 14% |
Immunology and Microbiology | 17 | 13% |
Chemistry | 3 | 2% |
Other | 14 | 11% |
Unknown | 33 | 26% |