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High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells

Overview of attention for article published in BMC Gastroenterology, January 2012
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Title
High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells
Published in
BMC Gastroenterology, January 2012
DOI 10.1186/1471-230x-12-4
Pubmed ID
Authors

Yoon-Ok Jang, Xianglan Quan, Ranjan Das, Shanhua Xu, Choon-Hee Chung, Chan Mug Ahn, Soon-Koo Baik, In Deok Kong, Kyu-Sang Park, Moon Young Kim

Abstract

Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been observed in patients with chronic HBV infection taking clevudine. Moreover, the development of diabetes was recently reported in patients receiving long-term treatment with clevudine. In this study, we investigated the effects of clevudine on mitochondrial function and insulin release in a rat clonal β-cell line, INS-1E.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iraq 1 4%
India 1 4%
Unknown 21 91%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 13%
Student > Ph. D. Student 3 13%
Student > Master 3 13%
Researcher 2 9%
Professor 1 4%
Other 3 13%
Unknown 8 35%
Readers by discipline Count As %
Medicine and Dentistry 5 22%
Agricultural and Biological Sciences 4 17%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Biochemistry, Genetics and Molecular Biology 1 4%
Nursing and Health Professions 1 4%
Other 2 9%
Unknown 8 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2012.
All research outputs
#18,303,566
of 22,661,413 outputs
Outputs from BMC Gastroenterology
#1,123
of 1,721 outputs
Outputs of similar age
#194,726
of 243,229 outputs
Outputs of similar age from BMC Gastroenterology
#20
of 28 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,721 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,229 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.