Title |
Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria
|
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Published in |
Malaria Journal, February 2016
|
DOI | 10.1186/s12936-016-1114-z |
Pubmed ID | |
Authors |
Tiphaine Gaillard, Jérôme Dormoi, Marylin Madamet, Bruno Pradines |
Abstract |
Malaria, a parasite vector-borne disease, is one of the biggest health threats in tropical regions, despite the availability of malaria chemoprophylaxis. The emergence and rapid extension of Plasmodium falciparum resistance to various anti-malarial drugs has gradually limited the potential malaria therapeutics available to clinicians. In this context, macrolides and associated antibiotics based on similar mechanism of action like lincosamides constitute an interesting alternative in the treatment of malaria. These molecules, whose action spectrum is similar to that of tetracyclines, are typically administered to children and pregnant women. Recent studies have examined the effects of azithromycin and the lincosamide clindamycin, on isolates from different continents. Azithromycin and clindamycin are effective and well tolerated in the treatment of uncomplicated malaria in combination with quinine. This literature review assesses the roles of macrolides and lincosamides in the prophylaxis and treatment of malaria. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 131 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 15% |
Student > Ph. D. Student | 17 | 13% |
Student > Master | 16 | 12% |
Researcher | 9 | 7% |
Student > Doctoral Student | 9 | 7% |
Other | 28 | 21% |
Unknown | 32 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 14% |
Biochemistry, Genetics and Molecular Biology | 17 | 13% |
Chemistry | 13 | 10% |
Agricultural and Biological Sciences | 12 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 8% |
Other | 19 | 15% |
Unknown | 41 | 31% |