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Widespread RNA binding by chromatin-associated proteins

Overview of attention for article published in Genome Biology (Online Edition), February 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

twitter
74 tweeters
peer_reviews
1 peer review site
facebook
2 Facebook pages

Citations

dimensions_citation
135 Dimensions

Readers on

mendeley
354 Mendeley
citeulike
1 CiteULike
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Title
Widespread RNA binding by chromatin-associated proteins
Published in
Genome Biology (Online Edition), February 2016
DOI 10.1186/s13059-016-0878-3
Pubmed ID
Authors

David G Hendrickson, David R. Kelley, Danielle Tenen, Bradley Bernstein, John L. Rinn

Abstract

Recent evidence suggests that RNA interaction can regulate the activity and localization of chromatin-associated proteins. However, it is unknown if these observations are specialized instances for a few key RNAs and chromatin factors in specific contexts, or a general mechanism underlying the establishment of chromatin state and regulation of gene expression. Here, we perform formaldehyde RNA immunoprecipitation (fRIP-Seq) to survey the RNA associated with a panel of 24 chromatin regulators and traditional RNA binding proteins. For each protein that reproducibly bound measurable quantities of bulk RNA (90 % of the panel), we detect enrichment for hundreds to thousands of both noncoding and mRNA transcripts. For each protein, we find that the enriched sets of RNAs share distinct biochemical, functional, and chromatin properties. Thus, these data provide evidence for widespread specific and relevant RNA association across diverse classes of chromatin-modifying complexes.

Twitter Demographics

The data shown below were collected from the profiles of 74 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 354 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 1%
United States 2 <1%
Czechia 2 <1%
Finland 1 <1%
Sweden 1 <1%
Brazil 1 <1%
France 1 <1%
Switzerland 1 <1%
Spain 1 <1%
Other 2 <1%
Unknown 337 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 119 34%
Researcher 73 21%
Student > Master 31 9%
Student > Doctoral Student 17 5%
Student > Bachelor 17 5%
Other 56 16%
Unknown 41 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 154 44%
Agricultural and Biological Sciences 121 34%
Computer Science 13 4%
Neuroscience 6 2%
Medicine and Dentistry 5 1%
Other 12 3%
Unknown 43 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2017.
All research outputs
#575,910
of 16,528,868 outputs
Outputs from Genome Biology (Online Edition)
#515
of 3,473 outputs
Outputs of similar age
#13,937
of 271,443 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 2 outputs
Altmetric has tracked 16,528,868 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,473 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them