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Tacrolimus toxicity in islet transplantation due to interaction with macrolides

Overview of attention for article published in Clinical Diabetes and Endocrinology, January 2016
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Title
Tacrolimus toxicity in islet transplantation due to interaction with macrolides
Published in
Clinical Diabetes and Endocrinology, January 2016
DOI 10.1186/s40842-016-0019-7
Pubmed ID
Authors

Kitty Kit-Ting Cheung, Peter Alexander Senior

Abstract

Drug interactions are an important risk in transplant patients. Case presentation: This case describes an incident where a patient with islet transplantation, who was using tacrolimus as part of the immunosuppressant regime, was started on a course of clarithromycin and experienced nephrotoxicity and neurotoxicity. He was an outpatient at that time and was managed with temporary cessation of tacrolimus until the tacrolimus level returned to target and his symptoms resolved. He recovered well and was resumed on his usual dosage of tacrolimus to prevent rejection of islets. Care should be taken with commonly used antibiotics to avoid potentially dangerous interactions with immunosuppressant drugs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 13%
Student > Doctoral Student 1 13%
Student > Master 1 13%
Researcher 1 13%
Student > Postgraduate 1 13%
Other 0 0%
Unknown 3 38%
Readers by discipline Count As %
Medicine and Dentistry 3 38%
Pharmacology, Toxicology and Pharmaceutical Science 2 25%
Unknown 3 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2020.
All research outputs
#14,249,851
of 22,849,304 outputs
Outputs from Clinical Diabetes and Endocrinology
#40
of 81 outputs
Outputs of similar age
#207,941
of 396,749 outputs
Outputs of similar age from Clinical Diabetes and Endocrinology
#4
of 6 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 81 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,749 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.