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Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA

Overview of attention for article published in BMC Genomics, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
1 blog
twitter
4 X users
patent
2 patents

Citations

dimensions_citation
55 Dimensions

Readers on

mendeley
111 Mendeley
citeulike
4 CiteULike
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Title
Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
Published in
BMC Genomics, January 2012
DOI 10.1186/1471-2164-13-28
Pubmed ID
Authors

Anastasios Mastrokolias, Johan T den Dunnen, GertJan B van Ommen, Peter AC 't Hoen, Willeke MC van Roon-Mom

Abstract

Transcriptome analysis is of great interest in clinical research, where significant differences between individuals can be translated into biomarkers of disease. Although next generation sequencing provides robust, comparable and highly informative expression profiling data, with several million of tags per blood sample, reticulocyte globin transcripts can constitute up to 76% of total mRNA compromising the detection of low abundant transcripts. We have removed globin transcripts from 6 human whole blood RNA samples with a human globin reduction kit and compared them with the same non-reduced samples using deep Serial Analysis of Gene Expression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 4%
United Kingdom 2 2%
South Africa 1 <1%
Brazil 1 <1%
Unknown 103 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 41 37%
Student > Ph. D. Student 20 18%
Other 9 8%
Student > Master 8 7%
Professor > Associate Professor 6 5%
Other 16 14%
Unknown 11 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 43%
Biochemistry, Genetics and Molecular Biology 23 21%
Medicine and Dentistry 9 8%
Immunology and Microbiology 2 2%
Environmental Science 2 2%
Other 11 10%
Unknown 16 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2022.
All research outputs
#2,650,375
of 23,979,951 outputs
Outputs from BMC Genomics
#832
of 10,871 outputs
Outputs of similar age
#21,149
of 252,104 outputs
Outputs of similar age from BMC Genomics
#20
of 278 outputs
Altmetric has tracked 23,979,951 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,871 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,104 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 278 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.