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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Overview of attention for article published in Molecular Neurodegeneration, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
twitter
2 X users
patent
2 patents

Citations

dimensions_citation
190 Dimensions

Readers on

mendeley
123 Mendeley
citeulike
1 CiteULike
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Title
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Published in
Molecular Neurodegeneration, January 2012
DOI 10.1186/1750-1326-7-2
Pubmed ID
Authors

Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen

Abstract

Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously reported that loss of LRRK2 causes impairment of protein degradation pathways as well as increases of apoptotic cell death and inflammatory responses in the kidney of aged mice.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 <1%
Kazakhstan 1 <1%
Spain 1 <1%
Russia 1 <1%
Unknown 117 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 33%
Researcher 28 23%
Student > Master 18 15%
Student > Bachelor 14 11%
Professor > Associate Professor 8 7%
Other 18 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 37%
Neuroscience 31 25%
Biochemistry, Genetics and Molecular Biology 22 18%
Medicine and Dentistry 13 11%
Chemistry 4 3%
Other 10 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2021.
All research outputs
#2,147,779
of 25,374,917 outputs
Outputs from Molecular Neurodegeneration
#253
of 977 outputs
Outputs of similar age
#15,215
of 248,338 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 21 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.