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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Understanding the mechanisms of aromatase inhibitor resistance
|
|---|---|
| Published in |
Breast Cancer Research, January 2012
|
| DOI | 10.1186/bcr2931 |
| Pubmed ID | |
| Authors |
William R Miller, Alexey A Larionov |
| Abstract |
ABSTRACT: Aromatase inhibitors (AIs) have a central role in the treatment of breast cancer; however, resistance is a major obstacle to optimal management. Evidence from endocrine, molecular and pathological measurements in clinical material taken before and after therapy with AIs and data from clinical trials in which AIs have been given as treatment either alone or in combination with other targeted agents suggest diverse causes for resistance. These include inherent tumour insensitivity to oestrogen, ineffective inhibition of aromatase, sources of oestrogenic hormones independent of aromatase, activation of signalling by non-endocrine pathways, enhanced cell survival and selection of hormone-insensitive cellular clones during treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| France | 1 | <1% |
| Unknown | 116 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 19% |
| Student > Ph. D. Student | 18 | 15% |
| Student > Master | 17 | 14% |
| Researcher | 15 | 13% |
| Student > Postgraduate | 8 | 7% |
| Other | 18 | 15% |
| Unknown | 19 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 24% |
| Medicine and Dentistry | 24 | 20% |
| Biochemistry, Genetics and Molecular Biology | 13 | 11% |
| Chemistry | 10 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 8% |
| Other | 10 | 8% |
| Unknown | 23 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2023.
All research outputs
#2,147,457
of 25,373,627 outputs
Outputs from Breast Cancer Research
#199
of 2,052 outputs
Outputs of similar age
#15,519
of 251,408 outputs
Outputs of similar age from Breast Cancer Research
#1
of 40 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,408 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.