Title |
Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties
|
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Published in |
BMC Systems Biology, December 2009
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DOI | 10.1186/1752-0509-3-120 |
Pubmed ID | |
Authors |
Guido Melzer, Manely Eslahpazir Esfandabadi, Ezequiel Franco-Lara, Christoph Wittmann |
Abstract |
The identification of genetic target genes is a key step for rational engineering of production strains towards bio-based chemicals, fuels or therapeutics. This is often a difficult task, because superior production performance typically requires a combination of multiple targets, whereby the complex metabolic networks complicate straightforward identification. Recent attempts towards target prediction mainly focus on the prediction of gene deletion targets and therefore can cover only a part of genetic modifications proven valuable in metabolic engineering. Efficient in silico methods for simultaneous genome-scale identification of targets to be amplified or deleted are still lacking. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 5 | 3% |
Netherlands | 2 | 1% |
United Kingdom | 2 | 1% |
China | 2 | 1% |
Iran, Islamic Republic of | 2 | 1% |
Sweden | 2 | 1% |
Kenya | 1 | <1% |
India | 1 | <1% |
Portugal | 1 | <1% |
Other | 4 | 2% |
Unknown | 166 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 27% |
Researcher | 37 | 20% |
Student > Master | 33 | 18% |
Student > Doctoral Student | 12 | 6% |
Professor > Associate Professor | 8 | 4% |
Other | 24 | 13% |
Unknown | 24 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 95 | 51% |
Biochemistry, Genetics and Molecular Biology | 28 | 15% |
Engineering | 17 | 9% |
Chemical Engineering | 4 | 2% |
Computer Science | 4 | 2% |
Other | 8 | 4% |
Unknown | 32 | 17% |