Title |
An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males
|
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Published in |
Journal of the International Society of Sports Nutrition, May 2022
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DOI | 10.1186/1550-2783-5-12 |
Pubmed ID | |
Authors |
Fru Angwafor, Mark L Anderson |
Abstract |
Maintaining endogenous testosterone (T) levels as men age may slow the symptoms of sarcopenia, andropause and decline in physical performance. Drugs inhibiting the enzyme 5alpha-reductase (5AR) produce increased blood levels of T and decreased levels of dihydrotestosterone (DHT). However, symptoms of gynecomastia have been reported due to the aromatase (AER) enzyme converting excess T to estradiol (ES). The carotenoid astaxanthin (AX) from Haematococcus pluvialis, Saw Palmetto berry lipid extract (SPLE) from Serenoa repens and the precise combination of these dietary supplements, Alphastat(R) (Mytosterone(trade mark)), have been reported to have inhibitory effects on both 5AR and AER in-vitro. Concomitant regulation of both enzymes in-vivo would cause DHT and ES blood levels to decrease and T levels to increase. The purpose of this clinical study was to determine if patented Alphastat(R) (Mytosterone(trade mark)) could produce these effects in a dose dependent manner. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 4 | 36% |
United States | 2 | 18% |
Brazil | 1 | 9% |
Unknown | 4 | 36% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 91% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
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New Zealand | 1 | 2% |
Germany | 1 | 2% |
Unknown | 42 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 7 | 16% |
Student > Ph. D. Student | 7 | 16% |
Researcher | 6 | 14% |
Student > Bachelor | 5 | 11% |
Student > Master | 5 | 11% |
Other | 7 | 16% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 15 | 34% |
Medicine and Dentistry | 10 | 23% |
Neuroscience | 2 | 5% |
Sports and Recreations | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 5 | 11% |
Unknown | 9 | 20% |