Title |
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
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Published in |
Nutrition & Metabolism, February 2007
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DOI | 10.1186/1743-7075-4-5 |
Pubmed ID | |
Authors |
Weihua Zhou, Purna Mukherjee, Michael A Kiebish, William T Markis, John G Mantis, Thomas N Seyfried |
Abstract |
Malignant brain cancer persists as a major disease of morbidity and mortality in adults and is the second leading cause of cancer death in children. Many current therapies for malignant brain tumors fail to provide long-term management because they ineffectively target tumor cells while negatively impacting the health and vitality of normal brain cells. In contrast to brain tumor cells, which lack metabolic flexibility and are largely dependent on glucose for growth and survival, normal brain cells can metabolize both glucose and ketone bodies for energy. This study evaluated the efficacy of KetoCal, a new nutritionally balanced high fat/low carbohydrate ketogenic diet for children with epilepsy, on the growth and vascularity of a malignant mouse astrocytoma (CT-2A) and a human malignant glioma (U87-MG). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 13% |
Spain | 11 | 12% |
Canada | 5 | 6% |
Mexico | 3 | 3% |
South Africa | 2 | 2% |
Venezuela, Bolivarian Republic of | 2 | 2% |
United Kingdom | 2 | 2% |
Malaysia | 1 | 1% |
Brazil | 1 | 1% |
Other | 8 | 9% |
Unknown | 42 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 66 | 74% |
Practitioners (doctors, other healthcare professionals) | 17 | 19% |
Scientists | 6 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Germany | 1 | <1% |
Israel | 1 | <1% |
Portugal | 1 | <1% |
Canada | 1 | <1% |
India | 1 | <1% |
Spain | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 378 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 79 | 20% |
Student > Bachelor | 57 | 15% |
Researcher | 45 | 12% |
Student > Ph. D. Student | 35 | 9% |
Other | 31 | 8% |
Other | 67 | 17% |
Unknown | 74 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 103 | 27% |
Agricultural and Biological Sciences | 59 | 15% |
Biochemistry, Genetics and Molecular Biology | 38 | 10% |
Nursing and Health Professions | 36 | 9% |
Neuroscience | 12 | 3% |
Other | 59 | 15% |
Unknown | 81 | 21% |