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Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

Overview of attention for article published in BMC Cancer, January 2012
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Title
Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
Published in
BMC Cancer, January 2012
DOI 10.1186/1471-2407-12-35
Pubmed ID
Authors

Anne-Katrine Bonde, Verena Tischler, Sushil Kumar, Alex Soltermann, Reto A Schwendener

Abstract

Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in this process they mainly assume a tumor promoting phenotype. In this study, we asked if TAMs also regulate EMT intratumorally. We found that TAMs through TGF-β signaling and activation of the β-catenin pathway can induce EMT in intratumoral cancer cells.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Mexico 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 216 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 55 25%
Researcher 33 15%
Student > Master 28 13%
Student > Bachelor 20 9%
Student > Postgraduate 15 7%
Other 34 15%
Unknown 37 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 23%
Biochemistry, Genetics and Molecular Biology 44 20%
Medicine and Dentistry 39 18%
Immunology and Microbiology 15 7%
Engineering 10 5%
Other 21 9%
Unknown 41 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2012.
All research outputs
#15,241,801
of 22,662,201 outputs
Outputs from BMC Cancer
#4,098
of 8,239 outputs
Outputs of similar age
#163,070
of 246,185 outputs
Outputs of similar age from BMC Cancer
#36
of 70 outputs
Altmetric has tracked 22,662,201 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,239 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,185 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.