Title |
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways
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Published in |
Radiation Oncology, October 2011
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DOI | 10.1186/1748-717x-6-144 |
Pubmed ID | |
Authors |
Ayesha Rashid, Caiqiong Liu, Toran Sanli, Evangelia Tsiani, Gurmit Singh, Robert G Bristow, Ian Dayes, Himu Lukka, James Wright, Theodoros Tsakiridis |
Abstract |
Prostate cancer (PrCa) displays resistance to radiotherapy (RT) and requires radiotherapy dose escalation which is associated with greater toxicity. This highlights a need to develop radiation sensitizers to improve the efficacy of RT in PrCa. Ionizing radiation (IR) stimulates pathways of IR-resistance and survival mediated by the protein kinase Akt but it also activates the metabolic energy sensor and tumor suppressor AMP-Activated Protein Kinase (AMPK). Here, we examined the effects of the polyphenol resveratrol (RSV) on the IR-induced inhibition of cell survival, modulation of cell cycle and molecular responses in PrCa cells. |
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Mendeley readers
Geographical breakdown
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Student > Doctoral Student | 7 | 12% |
Researcher | 6 | 10% |
Student > Bachelor | 5 | 9% |
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Unknown | 10 | 17% |
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