Title |
Resveratrol Engages AMPK to Attenuate ERK and mTOR Signaling in Sensory Neurons and Inhibits Incision-Induced Acute and Chronic Pain
|
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Published in |
Molecular Pain, January 2012
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DOI | 10.1186/1744-8069-8-5 |
Pubmed ID | |
Authors |
Dipti V Tillu, Ohannes K Melemedjian, Marina N Asiedu, Ning Qu, Milena De Felice, Gregory Dussor, Theodore J Price |
Abstract |
Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover, surgery has been implicated as a major cause of chronic pain conditions. Hence, more efficacious treatments are needed to inhibit incision-induced pain and prevent the transition to chronic pain following surgery. We reasoned that activators of AMP-activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision-induced pain because AMPK activators inhibit ERK and mTOR signaling, two important pathways involved in the sensitization of peripheral nociceptors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
New Zealand | 1 | 25% |
Trinidad and Tobago | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 1 | <1% |
France | 1 | <1% |
Czechia | 1 | <1% |
United Kingdom | 1 | <1% |
Russia | 1 | <1% |
United States | 1 | <1% |
Unknown | 116 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 18% |
Student > Ph. D. Student | 20 | 16% |
Student > Master | 20 | 16% |
Student > Doctoral Student | 10 | 8% |
Student > Bachelor | 10 | 8% |
Other | 22 | 18% |
Unknown | 18 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 28% |
Medicine and Dentistry | 24 | 20% |
Neuroscience | 15 | 12% |
Biochemistry, Genetics and Molecular Biology | 12 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
Other | 7 | 6% |
Unknown | 24 | 20% |