↓ Skip to main content

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

Overview of attention for article published in Journal of Translational Medicine, December 2011
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

twitter
4 X users
facebook
1 Facebook page

Citations

dimensions_citation
77 Dimensions

Readers on

mendeley
76 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors
Published in
Journal of Translational Medicine, December 2011
DOI 10.1186/1479-5876-9-221
Pubmed ID
Authors

Enrico P Spugnini, Alfonso Baldi, Sabrina Buglioni, Francesca Carocci, Giulia Milesi de Bazzichini, Gianluca Betti, Ilaria Pantaleo, Francesco Menicagli, Gennaro Citro, Stefano Fais

Abstract

The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs. Mechanisms underlying this resistance are far from being entirely known. A very efficient mechanism of tumor resistance to drugs is related to the modification of tumour microenvironment through changes in the extracellular and intracellular pH. The acidification of tumor microenvironment depends on proton pumps that actively pump protons outside the cells, mostly to avoid intracellular acidification. In fact, we have shown in pre-clinical settings as pre-treatment with proton-pumps inhibitors (PPI) increase tumor cell and tumor responsiveness to chemotherapeutics. In this study pet with spontaneously occurring cancer proven refractory to conventional chemotherapy have been recruited in a compassionate study.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 17%
Researcher 10 13%
Other 7 9%
Student > Doctoral Student 6 8%
Student > Postgraduate 6 8%
Other 14 18%
Unknown 20 26%
Readers by discipline Count As %
Medicine and Dentistry 22 29%
Veterinary Science and Veterinary Medicine 7 9%
Biochemistry, Genetics and Molecular Biology 6 8%
Psychology 6 8%
Agricultural and Biological Sciences 5 7%
Other 8 11%
Unknown 22 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2014.
All research outputs
#13,359,802
of 22,662,201 outputs
Outputs from Journal of Translational Medicine
#1,572
of 3,951 outputs
Outputs of similar age
#146,497
of 243,691 outputs
Outputs of similar age from Journal of Translational Medicine
#26
of 61 outputs
Altmetric has tracked 22,662,201 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,951 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,691 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.