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Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer

Overview of attention for article published in BMC Cancer, February 2016
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1 tweeter

Citations

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13 Mendeley
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Title
Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer
Published in
BMC Cancer, February 2016
DOI 10.1186/s12885-016-2126-3
Pubmed ID
Authors

Lu Zheng, Da Li, Yi-Ming Zhou, Hui Yang, Di Cheng, Xiao-Xin Ma

Abstract

The receptor for advanced glycation endproducts (RAGE) and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial cancer remains largely unknown. RAGE expression and microvessel density were examined in 20 cases of normal endometrial tissue, 37 cases of well-differentiated endometrial cancer tissue, and 35 cases of poorly-differentiated endometrial cancer tissue. Regression analysis was used to examine the relationship between RAGE and microvessel density. The knockdown of RAGE was achieved using a small interfering RNA in HEC-1A endometrial cancer cells. A xenografted tumour model was used to evaluate RAGE-mediated microvascular formation and proliferation of endometrial cancer cells. It was shown that (i) RAGE expression gradually increased in normal endometrium, well-differentiated endometrial cancer, and poorly-differentiated endometrial cancer, respectively; (ii) a positive correlation existed between RAGE and microvessel density in human endometrial cancer samples; (iii) RAGE knockdown was effective in decreasing microvessel formation in xenografted tumour models; and (iv) RAGE knockdown can significantly inhibit the proliferation of endometrial cancer cells in vivo. These results indicate that RAGE may be a potential trigger in microvascular formation and proliferation in the development of endometrial cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Slovenia 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 31%
Student > Ph. D. Student 3 23%
Unspecified 1 8%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Other 2 15%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 2 15%
Biochemistry, Genetics and Molecular Biology 2 15%
Business, Management and Accounting 2 15%
Agricultural and Biological Sciences 1 8%
Immunology and Microbiology 1 8%
Other 2 15%
Unknown 3 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2016.
All research outputs
#6,223,446
of 7,216,446 outputs
Outputs from BMC Cancer
#2,601
of 3,210 outputs
Outputs of similar age
#238,368
of 283,938 outputs
Outputs of similar age from BMC Cancer
#136
of 184 outputs
Altmetric has tracked 7,216,446 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,210 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,938 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 184 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.