RT @renesugar: Control of viral infections by epigenetic-targeted therapy #LongCovid #MECFS https://t.co/XT5CNu1NWH
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"Attractively, the monoamine oxidase inhibitor (MAOi) tranylcypromine repressed HSV IE gene expression and genome replication in vivo," https://t.co/jVdTwg5wM7
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LSD1 inhibitor, tranylcypromine (TCP) "resulted in a decrease in the expression of HCMV IE genes UL37, UL72, and US3 with a noted potent inhibition of IE gene expression with ML324." https://t.co/WLzmwiDqlm
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https://t.co/XT5CNu1NWH "This is explained by the ability of MAOis to inhibit the LSD-1 mediated demethylation of lysine residues via a flavin-adenine-dinucleotide-dependent reaction, resulting in the accumulation of repressive H3K9 chromatin marks at the