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The role of melatonin as an antioxidant in the follicle

Overview of attention for article published in Journal of Ovarian Research, January 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 499)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
4 news outlets
twitter
3 tweeters

Citations

dimensions_citation
161 Dimensions

Readers on

mendeley
50 Mendeley
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Title
The role of melatonin as an antioxidant in the follicle
Published in
Journal of Ovarian Research, January 2012
DOI 10.1186/1757-2215-5-5
Pubmed ID
Authors

Hiroshi Tamura, Akihisa Takasaki, Toshiaki Taketani, Manabu Tanabe, Fumie Kizuka, Lifa Lee, Isao Tamura, Ryo Maekawa, Hiromi Aasada, Yoshiaki Yamagata, Norihiro Sugino

Abstract

Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by pineal gland, and it regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction. It has been believed that melatonin regulates ovarian function by the regulation of gonadotropin release in the hypothalamus-pituitary gland axis via its specific receptors. In addition to the receptor mediated action, the discovery of melatonin as a direct free radical scavenger has greatly broadened the understanding of melatonin's mechanisms which benefit reproductive physiology. Higher concentrations of melatonin have been found in human preovulatory follicular fluid compared to serum, and there is growing evidence of the direct effects of melatonin on ovarian function especially oocyte maturation and embryo development. Many scientists have focused on the direct role of melatonin on oocyte maturation and embryo development as an anti-oxidant to reduce oxidative stress induced by reactive oxygen species, which are produced during ovulation process. The beneficial effects of melatonin administration on oocyte maturation and embryo development have been confirmed by in vitro and in vivo experiments in animals. This review also discusses the first application of melatonin to the clinical treatment of infertile women and confirms that melatonin administration reduces intrafollicular oxidative damage and increase fertilization rates. This review summarizes our recent works and new findings related to the reported beneficial effects of melatonin on reproductive physiology in its role as a reducer of oxidative stress, especially on oocyte maturation and embryo development.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Russia 1 2%
Brazil 1 2%
Unknown 47 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Student > Bachelor 7 14%
Researcher 5 10%
Student > Doctoral Student 4 8%
Student > Postgraduate 4 8%
Other 8 16%
Unknown 12 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 36%
Biochemistry, Genetics and Molecular Biology 5 10%
Medicine and Dentistry 4 8%
Veterinary Science and Veterinary Medicine 3 6%
Neuroscience 2 4%
Other 2 4%
Unknown 16 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2021.
All research outputs
#757,126
of 19,957,201 outputs
Outputs from Journal of Ovarian Research
#6
of 499 outputs
Outputs of similar age
#5,960
of 238,641 outputs
Outputs of similar age from Journal of Ovarian Research
#1
of 6 outputs
Altmetric has tracked 19,957,201 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 499 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,641 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them