Title |
Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis
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Published in |
BMC Neuroscience, January 2012
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DOI | 10.1186/1471-2202-13-12 |
Pubmed ID | |
Authors |
Alessandro Massella, Giulia D'Intino, Mercedes Fernández, Sandra Sivilia, Luca Lorenzini, Silvia Giatti, Roberto C Melcangi, Laura Calzà, Luciana Giardino |
Abstract |
Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have explored molecular mechanisms possibly involved in gender-related differences. The present study describes possible cellular- and molecular-involved markers which are differentially regulated in male and female rats and result in gender-dependent EAE evolution and progression. Attention was focused on markers of myelination (MBP and PDGFαR) and neuronal distress and/or damage (GABA synthesis enzymes, GAD65 and GAD67, NGF, BDNF and related receptors), in two CNS areas, i.e. spinal cord and cerebellum, which are respectively severely and mildly affected by inflammation and demyelination. Tissues were sampled during acute, relapse/remission and chronic phases and results were analysed by two-way ANOVA. |
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Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 1% |
Ireland | 1 | 1% |
Italy | 1 | 1% |
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 76 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 26% |
Student > Ph. D. Student | 17 | 21% |
Student > Master | 10 | 12% |
Student > Doctoral Student | 8 | 10% |
Student > Postgraduate | 4 | 5% |
Other | 10 | 12% |
Unknown | 11 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 21 | 26% |
Neuroscience | 15 | 19% |
Medicine and Dentistry | 9 | 11% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Veterinary Science and Veterinary Medicine | 4 | 5% |
Other | 7 | 9% |
Unknown | 18 | 22% |