VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases

@CatEye0611 @OpenMedF @JanetDafoe Huh wow .... that sncRNA-u14 binds to the EDD protein, which is an E3 ubiquitin ligase that targets ..... TERT! as a degradation substrate ...... makes sense. Take out the telomerase and the cell becomes senescent. https:/