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The protective effects of plasma gelsolin on stroke outcome in rats

Overview of attention for article published in Experimental & Translational Stroke Medicine, November 2011
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Title
The protective effects of plasma gelsolin on stroke outcome in rats
Published in
Experimental & Translational Stroke Medicine, November 2011
DOI 10.1186/2040-7378-3-13
Pubmed ID
Authors

Huong T Le, Aaron C Hirko, Jeffrey S Thinschmidt, Maria Grant, Zhimin Li, Joanna Peris, Michael A King, Jeffrey A Hughes, Sihong Song

Abstract

To date, recombinant tissue plasminogen activator (rtPA) is the only approved drug for ischemic stroke. It is intravenously administered functioning as a thrombolytic agent and is used to obtain reperfusion of the affected area of the brain. Excitotoxicity, inflammation and apoptosis are all involved in delayed neuronal death following stroke and offer multiple opportunities to intervene with neuroprotective agents. Gelsolin (GSN) is an actin- and calcium-binding protein mediating the disassembly of actin filaments and activity of calcium channels. It also functions as a regulator of apoptosis and inflammatory responses. This study tests the hypothesis that increasing the concentration of the form of GSN known as plasma GSN (pGSN) near an infarct will provide neuroprotection following ischemic stroke.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Researcher 4 17%
Student > Doctoral Student 2 8%
Professor 2 8%
Student > Master 2 8%
Other 4 17%
Unknown 6 25%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Agricultural and Biological Sciences 4 17%
Biochemistry, Genetics and Molecular Biology 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Psychology 1 4%
Other 3 13%
Unknown 7 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2012.
All research outputs
#15,241,801
of 22,662,201 outputs
Outputs from Experimental & Translational Stroke Medicine
#26
of 41 outputs
Outputs of similar age
#96,465
of 141,803 outputs
Outputs of similar age from Experimental & Translational Stroke Medicine
#2
of 3 outputs
Altmetric has tracked 22,662,201 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 41 research outputs from this source. They receive a mean Attention Score of 3.6. This one scored the same or higher as 15 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,803 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.