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Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

Overview of attention for article published in BMC Pharmacology and Toxicology, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#18 of 367)
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
5 tweeters
reddit
1 Redditor

Citations

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66 Dimensions

Readers on

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118 Mendeley
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Title
Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
Published in
BMC Pharmacology and Toxicology, February 2016
DOI 10.1186/s40360-016-0052-2
Pubmed ID
Authors

Lars P. H. Andersen, Mads U. Werner, Mette M. Rosenkilde, Nathja G. Harpsøe, Hanne Fuglsang, Jacob Rosenberg, Ismail Gögenur

Abstract

The aim was to investigate the pharmacokinetics of oral and iv melatonin in healthy volunteers. The study was performed as a cohort crossover study. The volunteers received either 10 mg oral melatonin or 10 mg intravenous melatonin on two separate study days. Blood samples were collected at different time points following oral administration and short iv infusion, respectively. Plasma melatonin concentrations were determined by RIA technique. Pharmacokinetic analyses were performed by "the method of residuals" and compartmental analysis. The pharmacokinetic variables: k a, t 1/2 absorption, t max, C max, t 1/2 elimination, AUC 0-∞, and bioavailability were determined for oral melatonin. C max, t 1/2 elimination, V d, CL and AUC 0-∞ were determined for intravenous melatonin. Twelve male volunteers completed the study. Baseline melatonin plasma levels did not differ significantly between the study days (P = 0.067). Mean (SD) t 1/2 absorption of oral melatonin was 6.0 (3.1) min. Mean t max was 40.8 (17.8) min with a median (IQR) C max of 3550.5 (2500.5-8057.5) pg ml(-1). Mean t 1/2 elimination was 53.7 (7.0) min. Median absolute bioavailability was 2.5 (1.7-4.7) %. Median C max after short iv infusion of melatonin was 389,875.0 (174,775.0-440,362.5) pg ml(-1). Mean t 1/2 elimination was 39.4 (3.6) min, mean V d 1.2 (0.6) l kg(-1) and mean CL 0.0218 (0.0102) l min(-1) kg(-1). This cohort crossover study estimated pharmacokinetics of oral and iv melatonin, respectively in healthy volunteers. Bioavailability of oral melatonin was only 3 %. Eudra-CT number: 2013-000205-23 (initial registration 27.03.2013). Clinicaltrials.gov Identifier: NCT01923974 (initial registration 08.08.2013).

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 <1%
Spain 1 <1%
Unknown 116 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 14%
Researcher 15 13%
Other 14 12%
Student > Bachelor 12 10%
Professor 9 8%
Other 30 25%
Unknown 22 19%
Readers by discipline Count As %
Medicine and Dentistry 34 29%
Pharmacology, Toxicology and Pharmaceutical Science 14 12%
Agricultural and Biological Sciences 10 8%
Biochemistry, Genetics and Molecular Biology 7 6%
Neuroscience 4 3%
Other 17 14%
Unknown 32 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2021.
All research outputs
#1,004,630
of 18,881,749 outputs
Outputs from BMC Pharmacology and Toxicology
#18
of 367 outputs
Outputs of similar age
#20,175
of 273,369 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#1
of 4 outputs
Altmetric has tracked 18,881,749 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 367 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them