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Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

Overview of attention for article published in BMC Pharmacology and Toxicology, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 450)
  • High Attention Score compared to outputs of the same age (92nd percentile)

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2 news outlets
blogs
1 blog
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5 X users
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1 Redditor

Citations

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123 Dimensions

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174 Mendeley
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Title
Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
Published in
BMC Pharmacology and Toxicology, February 2016
DOI 10.1186/s40360-016-0052-2
Pubmed ID
Authors

Lars P. H. Andersen, Mads U. Werner, Mette M. Rosenkilde, Nathja G. Harpsøe, Hanne Fuglsang, Jacob Rosenberg, Ismail Gögenur

Abstract

The aim was to investigate the pharmacokinetics of oral and iv melatonin in healthy volunteers. The study was performed as a cohort crossover study. The volunteers received either 10 mg oral melatonin or 10 mg intravenous melatonin on two separate study days. Blood samples were collected at different time points following oral administration and short iv infusion, respectively. Plasma melatonin concentrations were determined by RIA technique. Pharmacokinetic analyses were performed by "the method of residuals" and compartmental analysis. The pharmacokinetic variables: k a, t 1/2 absorption, t max, C max, t 1/2 elimination, AUC 0-∞, and bioavailability were determined for oral melatonin. C max, t 1/2 elimination, V d, CL and AUC 0-∞ were determined for intravenous melatonin. Twelve male volunteers completed the study. Baseline melatonin plasma levels did not differ significantly between the study days (P = 0.067). Mean (SD) t 1/2 absorption of oral melatonin was 6.0 (3.1) min. Mean t max was 40.8 (17.8) min with a median (IQR) C max of 3550.5 (2500.5-8057.5) pg ml(-1). Mean t 1/2 elimination was 53.7 (7.0) min. Median absolute bioavailability was 2.5 (1.7-4.7) %. Median C max after short iv infusion of melatonin was 389,875.0 (174,775.0-440,362.5) pg ml(-1). Mean t 1/2 elimination was 39.4 (3.6) min, mean V d 1.2 (0.6) l kg(-1) and mean CL 0.0218 (0.0102) l min(-1) kg(-1). This cohort crossover study estimated pharmacokinetics of oral and iv melatonin, respectively in healthy volunteers. Bioavailability of oral melatonin was only 3 %. Eudra-CT number: 2013-000205-23 (initial registration 27.03.2013). Clinicaltrials.gov Identifier: NCT01923974 (initial registration 08.08.2013).

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 174 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 <1%
Spain 1 <1%
Unknown 172 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 13%
Researcher 18 10%
Other 15 9%
Student > Bachelor 15 9%
Professor 9 5%
Other 33 19%
Unknown 61 35%
Readers by discipline Count As %
Medicine and Dentistry 36 21%
Pharmacology, Toxicology and Pharmaceutical Science 16 9%
Agricultural and Biological Sciences 12 7%
Biochemistry, Genetics and Molecular Biology 9 5%
Neuroscience 4 2%
Other 22 13%
Unknown 75 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2021.
All research outputs
#1,289,077
of 23,340,595 outputs
Outputs from BMC Pharmacology and Toxicology
#20
of 450 outputs
Outputs of similar age
#22,631
of 299,072 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#1
of 4 outputs
Altmetric has tracked 23,340,595 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 450 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,072 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them