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Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials

Overview of attention for article published in Alzheimer's Research & Therapy, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet
twitter
6 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
81 Dimensions

Readers on

mendeley
138 Mendeley
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Title
Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials
Published in
Alzheimer's Research & Therapy, February 2016
DOI 10.1186/s13195-016-0176-z
Pubmed ID
Authors

Kimberly R. Chapman, Hanaan Bing-Canar, Michael L. Alosco, Eric G. Steinberg, Brett Martin, Christine Chaisson, Neil Kowall, Yorghos Tripodis, Robert A. Stern

Abstract

Specific cutoff scores on the Mini Mental State Examination (MMSE) and the Logical Memory (LM) test are used to determine inclusion in Alzheimer's disease (AD) clinical trials and diagnostic studies. These screening measures have known psychometric limitations, but no study has examined the diagnostic accuracy of the cutoff scores used to determine entry into AD clinical trials and diagnostic studies. ClinicalTrials.gov entries were reviewed for phases II and III active and recruiting AD studies using the MMSE and LM for inclusion. The diagnostic accuracy of MMSE and LM-II cutoffs used in AD trials and diagnostic studies was examined using 23,438 subjects with normal cognition, mild cognitive impairment (MCI), and AD dementia derived from the National Alzheimer's Coordinating Center database. MMSE and LM cutoffs used in current AD clinical trials and diagnostic studies had limited diagnostic accuracy, particularly for distinguishing between normal cognition and MCI, and MCI from AD dementia. The MMSE poorly discriminated dementia stage. The MMSE and LM may result in inappropriate subject enrollment in large-scale, multicenter studies designed to develop therapeutics and diagnostic methods for AD.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Australia 1 <1%
Unknown 136 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 23 17%
Student > Master 16 12%
Student > Ph. D. Student 15 11%
Researcher 14 10%
Student > Postgraduate 10 7%
Other 24 17%
Unknown 36 26%
Readers by discipline Count As %
Medicine and Dentistry 25 18%
Psychology 23 17%
Neuroscience 16 12%
Nursing and Health Professions 6 4%
Agricultural and Biological Sciences 5 4%
Other 19 14%
Unknown 44 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2023.
All research outputs
#2,144,430
of 23,005,189 outputs
Outputs from Alzheimer's Research & Therapy
#457
of 1,241 outputs
Outputs of similar age
#36,169
of 299,297 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#8
of 14 outputs
Altmetric has tracked 23,005,189 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,241 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.0. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,297 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.