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Efficacy of Vitamin D Supplementation in Multiple Sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial

Overview of attention for article published in Trials, February 2012
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Title
Efficacy of Vitamin D Supplementation in Multiple Sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial
Published in
Trials, February 2012
DOI 10.1186/1745-6215-13-15
Pubmed ID
Authors

Jan Dörr, Stephanie Ohlraun, Horst Skarabis, Friedemann Paul

Abstract

Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system in young adults. Despite the fact that numerous lines of evidence link both the risk of disease development and the disease course to the serum level of 25-hydroxyvitamin D it still remains elusive whether multiple sclerosis patients benefit from boosting the serum level of 25-hydroxyvitamin D, mainly because interventional clinical trials that directly address the therapeutic effects of vitamin D in multiple sclerosis are sparse. We here present the protocol of an interventional clinical phase II study to test the hypothesis, that high-dose vitamin D supplementation of multiple sclerosis patients is safe and superior to low-dose supplementation with respect to beneficial therapeutic effects.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 259 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 <1%
Portugal 1 <1%
New Zealand 1 <1%
Unknown 255 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 51 20%
Student > Bachelor 44 17%
Student > Ph. D. Student 18 7%
Student > Postgraduate 17 7%
Researcher 15 6%
Other 57 22%
Unknown 57 22%
Readers by discipline Count As %
Medicine and Dentistry 97 37%
Nursing and Health Professions 23 9%
Agricultural and Biological Sciences 20 8%
Biochemistry, Genetics and Molecular Biology 10 4%
Psychology 10 4%
Other 29 11%
Unknown 70 27%