Title |
Efficacy of Vitamin D Supplementation in Multiple Sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial
|
---|---|
Published in |
Trials, February 2012
|
DOI | 10.1186/1745-6215-13-15 |
Pubmed ID | |
Authors |
Jan Dörr, Stephanie Ohlraun, Horst Skarabis, Friedemann Paul |
Abstract |
Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system in young adults. Despite the fact that numerous lines of evidence link both the risk of disease development and the disease course to the serum level of 25-hydroxyvitamin D it still remains elusive whether multiple sclerosis patients benefit from boosting the serum level of 25-hydroxyvitamin D, mainly because interventional clinical trials that directly address the therapeutic effects of vitamin D in multiple sclerosis are sparse. We here present the protocol of an interventional clinical phase II study to test the hypothesis, that high-dose vitamin D supplementation of multiple sclerosis patients is safe and superior to low-dose supplementation with respect to beneficial therapeutic effects. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 71% |
United States | 1 | 14% |
Unknown | 1 | 14% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | <1% |
Portugal | 1 | <1% |
New Zealand | 1 | <1% |
Unknown | 255 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 51 | 20% |
Student > Bachelor | 44 | 17% |
Student > Ph. D. Student | 18 | 7% |
Student > Postgraduate | 17 | 7% |
Researcher | 15 | 6% |
Other | 57 | 22% |
Unknown | 57 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 97 | 37% |
Nursing and Health Professions | 23 | 9% |
Agricultural and Biological Sciences | 20 | 8% |
Biochemistry, Genetics and Molecular Biology | 10 | 4% |
Psychology | 10 | 4% |
Other | 29 | 11% |
Unknown | 70 | 27% |