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Deficiency of iNOS-derived NO accelerates lipid accumulation-independent liver fibrosis in non-alcoholic steatohepatitis mouse model

Overview of attention for article published in BMC Gastroenterology, April 2015
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

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Title
Deficiency of iNOS-derived NO accelerates lipid accumulation-independent liver fibrosis in non-alcoholic steatohepatitis mouse model
Published in
BMC Gastroenterology, April 2015
DOI 10.1186/s12876-015-0269-3
Pubmed ID
Authors

Yuichi Nozaki, Koji Fujita, Koichiro Wada, Masato Yoneda, Takaomi Kessoku, Yoshiyasu Shinohara, Kento Imajo, Yuji Ogawa, Makoto Nakamuta, Satoru Saito, Naohiko Masaki, Yoji Nagashima, Yasuo Terauchi, Atsushi Nakajima

Abstract

Although many of the factors and molecules closely associated with non-alcoholic steatohepatitis (NASH) have been reported, the role of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) on the progression of NASH remains unclear. We therefore investigated the role of iNOS-derived NO in NASH pathogenesis with a long-term follow-up study using systemic iNOS-knockout mice under high-fat diet (HFD) conditions. iNOS-knockout and wild-type mice were fed a basal or HFD for 10 or 48 weeks. Lipid accumulation, fibrosis, and inflammation were evaluated, and various factors and molecules closely associated with NASH were analyzed. Marked fibrosis and inflammation (indicators of NASH) were observed in the livers of iNOS-knockout mice compared to wild-type mice after 48 weeks of a HFD; however, lipid accumulation in iNOS-knockout mice livers was less than in the wild-type. Increased expressions of various cytokines that are transcriptionally controlled by NF-kB in iNOS-deficient mice livers were observed during HFD conditions. iNOS-derived NO may play a protective role against the progression to NASH during an HFD by preventing fibrosis and inflammation, which are mediated by NF-kB activation in Kupffer cells. A lack of iNOS-derived NO accelerates progression to NASH without excessive lipid accumulation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 21%
Researcher 7 18%
Student > Bachelor 5 13%
Student > Master 5 13%
Other 2 5%
Other 5 13%
Unknown 6 16%
Readers by discipline Count As %
Medicine and Dentistry 13 34%
Agricultural and Biological Sciences 6 16%
Biochemistry, Genetics and Molecular Biology 5 13%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Unspecified 1 3%
Other 2 5%
Unknown 8 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2022.
All research outputs
#7,350,669
of 23,172,045 outputs
Outputs from BMC Gastroenterology
#465
of 1,779 outputs
Outputs of similar age
#87,048
of 265,395 outputs
Outputs of similar age from BMC Gastroenterology
#11
of 27 outputs
Altmetric has tracked 23,172,045 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,779 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,395 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.