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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
|
|---|---|
| Published in |
Molecular Cancer, February 2016
|
| DOI | 10.1186/s12943-016-0502-x |
| Pubmed ID | |
| Authors |
Silvia Juliana Serrano-Gomez, Mazvita Maziveyi, Suresh K. Alahari |
| Abstract |
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal phenotype with invasive capacities. This phenomenon has been well documented in multiple biological processes including embryogenesis, fibrosis, tumor progression and metastasis. The hallmark of EMT is the loss of epithelial surface markers, most notably E-cadherin, and the acquisition of mesenchymal markers including vimentin and N-cadherin. The downregulation of E-cadherin during EMT can be mediated by its transcriptional repression through the binding of EMT transcription factors (EMT-TFs) such as SNAIL, SLUG and TWIST to E-boxes present in the E-cadherin promoter. Additionally, EMT-TFs can also cooperate with several enzymes to repress the expression of E-cadherin and regulate EMT at the epigenetic and post- translational level. In this review, we will focus on epigenetic and post- translational modifications that are important in EMT. In addition, we will provide an overview of the various therapeutic approaches currently being investigated to undermine EMT and hence, the metastatic progression of cancer as well. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 464 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | <1% |
| Unknown | 463 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 106 | 23% |
| Student > Bachelor | 68 | 15% |
| Student > Master | 56 | 12% |
| Researcher | 38 | 8% |
| Student > Doctoral Student | 26 | 6% |
| Other | 46 | 10% |
| Unknown | 124 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 149 | 32% |
| Agricultural and Biological Sciences | 61 | 13% |
| Medicine and Dentistry | 50 | 11% |
| Immunology and Microbiology | 10 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 2% |
| Other | 41 | 9% |
| Unknown | 144 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2016.
All research outputs
#17,789,675
of 22,851,489 outputs
Outputs from Molecular Cancer
#1,204
of 1,722 outputs
Outputs of similar age
#203,146
of 298,866 outputs
Outputs of similar age from Molecular Cancer
#13
of 22 outputs
Altmetric has tracked 22,851,489 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,722 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,866 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.