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Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

Overview of attention for article published in Molecular Cancer, February 2016
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Mentioned by

twitter
2 tweeters

Citations

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380 Dimensions

Readers on

mendeley
368 Mendeley
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Title
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
Published in
Molecular Cancer, February 2016
DOI 10.1186/s12943-016-0502-x
Pubmed ID
Authors

Silvia Juliana Serrano-Gomez, Mazvita Maziveyi, Suresh K. Alahari

Abstract

The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal phenotype with invasive capacities. This phenomenon has been well documented in multiple biological processes including embryogenesis, fibrosis, tumor progression and metastasis. The hallmark of EMT is the loss of epithelial surface markers, most notably E-cadherin, and the acquisition of mesenchymal markers including vimentin and N-cadherin. The downregulation of E-cadherin during EMT can be mediated by its transcriptional repression through the binding of EMT transcription factors (EMT-TFs) such as SNAIL, SLUG and TWIST to E-boxes present in the E-cadherin promoter. Additionally, EMT-TFs can also cooperate with several enzymes to repress the expression of E-cadherin and regulate EMT at the epigenetic and post- translational level. In this review, we will focus on epigenetic and post- translational modifications that are important in EMT. In addition, we will provide an overview of the various therapeutic approaches currently being investigated to undermine EMT and hence, the metastatic progression of cancer as well.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 368 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 <1%
Unknown 367 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 98 27%
Student > Bachelor 53 14%
Student > Master 49 13%
Researcher 32 9%
Student > Doctoral Student 21 6%
Other 38 10%
Unknown 77 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 125 34%
Agricultural and Biological Sciences 59 16%
Medicine and Dentistry 42 11%
Pharmacology, Toxicology and Pharmaceutical Science 8 2%
Immunology and Microbiology 6 2%
Other 34 9%
Unknown 94 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2016.
All research outputs
#5,251,512
of 7,295,661 outputs
Outputs from Molecular Cancer
#433
of 689 outputs
Outputs of similar age
#182,127
of 282,605 outputs
Outputs of similar age from Molecular Cancer
#11
of 22 outputs
Altmetric has tracked 7,295,661 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 689 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,605 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.