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Effect of Saccharomyces cerevisiae var. Boulardii and β-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88)

Overview of attention for article published in Veterinary Research, January 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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1 tweeter
facebook
1 Facebook page

Citations

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45 Dimensions

Readers on

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100 Mendeley
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Title
Effect of Saccharomyces cerevisiae var. Boulardii and β-galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged in vitro with Escherichia coli F4 (K88)
Published in
Veterinary Research, January 2012
DOI 10.1186/1297-9716-43-4
Pubmed ID
Authors

Roger Badia, Roger Badia, Galliano Zanello, Claire Chevaleyre, Rosil Lizardo, François Meurens, Paz Martínez, Joaquim Brufau, Henri Salmon

Abstract

Probiotic and prebiotics, often called "immune-enhancing" feed additives, are believed to deal with pathogens, preventing the need of an immune response and reducing tissue damage. In this study, we investigated if a recently developed β-galactomannan (βGM) had a similar protective role compared to Saccharomyces cerevisiae var. Boulardii (Scb), a proven probiotic, in the context of enterotoxigenic Escherichia coli (ETEC) infection. ETEC causes inflammation, diarrhea and intestinal damage in piglets, resulting in large economic loses worldwide. We observed that Scb and βGM products inhibited in vitro adhesion of ETEC on cell surface of porcine intestinal IPI-2I cells. Our data showed that Scb and βGM decreased the mRNA ETEC-induced gene expression of pro-inflammatory cytokines TNF-α, IL-6, GM-CSF and chemokines CCL2, CCL20 and CXCL8 on intestinal IPI-2I. Furthermore, we investigated the putative immunomodulatory role of Scb and βGM on porcine monocyte-derived dendritic cells (DCs) per se and under infection conditions. We observed a slight up-regulation of mRNA for TNF-α and CCR7 receptor after co-incubation of DC with Scb and βGM. However, no differences were found in DC activation upon ETEC infection and Scb or βGM co-culture. Therefore, our results indicate that, similar to probiotic Scb, prebiotic βGM may protect intestinal epithelial cells against intestinal pathogens. Finally, although these products may modulate DC activation, their effect under ETEC challenge conditions remains to be elucidated.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Brazil 1 1%
Slovenia 1 1%
Argentina 1 1%
Spain 1 1%
United States 1 1%
Unknown 94 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 19%
Researcher 17 17%
Student > Bachelor 14 14%
Student > Master 9 9%
Other 6 6%
Other 18 18%
Unknown 17 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 38%
Medicine and Dentistry 13 13%
Veterinary Science and Veterinary Medicine 12 12%
Biochemistry, Genetics and Molecular Biology 4 4%
Immunology and Microbiology 4 4%
Other 11 11%
Unknown 18 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2012.
All research outputs
#1,806,773
of 3,632,299 outputs
Outputs from Veterinary Research
#162
of 294 outputs
Outputs of similar age
#84,512
of 230,775 outputs
Outputs of similar age from Veterinary Research
#1
of 6 outputs
Altmetric has tracked 3,632,299 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 294 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,775 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them