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A general homeostatic principle following lesion induced dendritic remodeling

Overview of attention for article published in Acta Neuropathologica Communications, February 2016
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2 tweeters

Citations

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18 Dimensions

Readers on

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40 Mendeley
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Title
A general homeostatic principle following lesion induced dendritic remodeling
Published in
Acta Neuropathologica Communications, February 2016
DOI 10.1186/s40478-016-0285-8
Pubmed ID
Authors

Steffen Platschek, Hermann Cuntz, Mario Vuksic, Thomas Deller, Peter Jedlicka

Abstract

Neuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically altered and damaged. The functional consequences of this phenomenon are poorly understood. Using computational modelling of 3D-reconstructed granule cells we show that denervation-induced dendritic atrophy also subserves homeostatic functions: By shortening their dendritic tree, granule cells compensate for the loss of inputs by a precise adjustment of excitability. As a consequence, surviving afferents are able to activate the cells, thereby allowing information to flow again through the denervated area. In addition, action potentials backpropagating from the soma to the synapses are enhanced specifically in reorganized portions of the dendritic arbor, resulting in their increased synaptic plasticity. These two observations generalize to any given dendritic tree undergoing structural changes. Structural homeostatic plasticity, i.e. homeostatic dendritic remodeling, is operating in long-term denervated neurons to achieve functional homeostasis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 5%
Unknown 38 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 25%
Researcher 8 20%
Student > Ph. D. Student 5 13%
Student > Bachelor 4 10%
Student > Doctoral Student 3 8%
Other 6 15%
Unknown 4 10%
Readers by discipline Count As %
Neuroscience 20 50%
Medicine and Dentistry 7 18%
Agricultural and Biological Sciences 6 15%
Computer Science 1 3%
Unspecified 1 3%
Other 2 5%
Unknown 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2021.
All research outputs
#14,051,341
of 22,520,629 outputs
Outputs from Acta Neuropathologica Communications
#1,056
of 1,352 outputs
Outputs of similar age
#144,849
of 280,742 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 22,520,629 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,352 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,742 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them