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Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

Overview of attention for article published in Particle and Fibre Toxicology, February 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 540)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

twitter
60 tweeters

Citations

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96 Dimensions

Readers on

mendeley
85 Mendeley
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Title
Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)
Published in
Particle and Fibre Toxicology, February 2016
DOI 10.1186/s12989-016-0123-y
Pubmed ID
Authors

Giulia Vietti, Dominique Lison, Sybille van den Brule

Abstract

Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, not clearly elucidated. The purpose of the present review was to analyze the key events involved in the lung fibrotic reaction induced by CNT and to assess their relationships. We thus address current knowledge and gaps with a view to draft an Adverse Outcome Pathway (AOP) concerning the fibrotic potential of CNT.As for many inhaled particles, CNT can indirectly activate fibroblasts through the release of pro-inflammatory (IL-1β) and pro-fibrotic (PDGF and TGF-β) mediators by inflammatory cells (macrophages and epithelial cells) via the induction of oxidative stress, inflammasome or NF-kB. We also highlight here direct effects of CNT on fibroblasts, which appear as a new mode of toxicity relatively specific for CNT. Direct effects of CNT on fibroblasts include the induction of fibroblast proliferation, differentiation and collagen production via ERK 1/2 or Smad signaling. We also point out the physico-chemical properties of CNT important for their toxicity and the relationship between in vitro and in vivo effects. This knowledge provides evidence to draft an AOP for the fibrogenic activity of CNT, which allows developing simple in vitro models contributing to predict the CNT effects in lung fibrosis, and risk assessment tools for regulatory decision.

Twitter Demographics

The data shown below were collected from the profiles of 60 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Norway 1 1%
Unknown 84 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 24%
Researcher 19 22%
Student > Master 10 12%
Student > Doctoral Student 9 11%
Student > Bachelor 6 7%
Other 9 11%
Unknown 12 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 18%
Pharmacology, Toxicology and Pharmaceutical Science 8 9%
Biochemistry, Genetics and Molecular Biology 7 8%
Environmental Science 7 8%
Chemistry 6 7%
Other 21 25%
Unknown 21 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2022.
All research outputs
#654,816
of 21,454,959 outputs
Outputs from Particle and Fibre Toxicology
#21
of 540 outputs
Outputs of similar age
#12,944
of 279,636 outputs
Outputs of similar age from Particle and Fibre Toxicology
#1
of 1 outputs
Altmetric has tracked 21,454,959 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 540 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,636 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them