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Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system

Overview of attention for article published in BMC Structural Biology, February 2016
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2 tweeters

Citations

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23 Dimensions

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57 Mendeley
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Title
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system
Published in
BMC Structural Biology, February 2016
DOI 10.1186/s12900-016-0056-6
Pubmed ID
Authors

Jonathan M. Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg, Konstantin V. Korotkov

Abstract

The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system. This study characterizes the structures of the soluble domains of two conserved core ESX-1 components - EccB1 and EccD1. The periplasmic domain of EccB1 consists of 4 repeat domains and a central domain, which together form a quasi 2-fold symmetrical structure. The repeat domains of EccB1 are structurally similar to a known peptidoglycan binding protein suggesting a role in anchoring the ESX-1 system within the periplasmic space. The cytoplasmic domain of EccD1has a ubiquitin-like fold and forms a dimer with a negatively charged groove. These structures represent a major step towards resolving the molecular architecture of the entire ESX-1 assembly and may contribute to ESX-1 targeted tuberculosis intervention strategies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 23%
Student > Bachelor 10 18%
Student > Master 9 16%
Researcher 7 12%
Other 3 5%
Other 7 12%
Unknown 8 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 53%
Agricultural and Biological Sciences 7 12%
Immunology and Microbiology 4 7%
Chemistry 4 7%
Medicine and Dentistry 2 4%
Other 1 2%
Unknown 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2016.
All research outputs
#7,056,346
of 11,331,318 outputs
Outputs from BMC Structural Biology
#89
of 167 outputs
Outputs of similar age
#160,967
of 293,301 outputs
Outputs of similar age from BMC Structural Biology
#3
of 5 outputs
Altmetric has tracked 11,331,318 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 167 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,301 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.