Title |
Excitability of Aβ sensory neurons is altered in an animal model of peripheral neuropathy
|
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Published in |
BMC Neuroscience, January 2012
|
DOI | 10.1186/1471-2202-13-15 |
Pubmed ID | |
Authors |
Yong Fang Zhu, James L Henry |
Abstract |
Causes of neuropathic pain following nerve injury remain unclear, limiting the development of mechanism-based therapeutic approaches. Animal models have provided some directions, but little is known about the specific sensory neurons that undergo changes in such a way as to induce and maintain activation of sensory pain pathways. Our previous studies implicated changes in the Aβ, normally non-nociceptive neurons in activating spinal nociceptive neurons in a cuff-induced animal model of neuropathic pain and the present study was directed specifically at determining any change in excitability of these neurons. Thus, the present study aimed at recording intracellularly from Aβ-fiber dorsal root ganglion (DRG) neurons and determining excitability of the peripheral receptive field, of the cell body and of the dorsal roots. |
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