Title |
Bone marrow mononuclear cells and acute myocardial infarction
|
---|---|
Published in |
Stem Cell Research & Therapy, January 2012
|
DOI | 10.1186/scrt93 |
Pubmed ID | |
Authors |
Samer Arnous, Abdul Mozid, John Martin, Anthony Mathur |
Abstract |
Stem cell transplantation is emerging as a potential therapy to treat heart diseases. Promising results from early animal studies led to an explosion of small, non-controlled clinical trials that created even further excitement by showing that stem cell transplantation improved left ventricular systolic function and enhanced remodelling. However, the specific mechanisms by which these cells improve heart function remain largely unknown. A large variety of cell types have been considered to possess the regenerative ability needed to repair the damaged heart. One of the most studied cell types is the bone marrow-derived mononuclear cells and these form the focus of this review. This review article aims to provide an overview of their use in the setting of acute myocardial infarction, the challenges it faces and the future of stem cell therapy in heart disease. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 21% |
Student > Bachelor | 7 | 15% |
Student > Master | 6 | 13% |
Other | 3 | 6% |
Unspecified | 3 | 6% |
Other | 13 | 27% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 18 | 38% |
Agricultural and Biological Sciences | 7 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Unspecified | 3 | 6% |
Engineering | 3 | 6% |
Other | 6 | 13% |
Unknown | 6 | 13% |