Title |
Analysis of the MTHFR C677T variant with migraine phenotypes
|
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Published in |
BMC Research Notes, July 2010
|
DOI | 10.1186/1756-0500-3-213 |
Pubmed ID | |
Authors |
Annie Liu, Saraswathy Menon, Natalie J Colson, Sharon Quinlan, Hannah Cox, Madelyn Peterson, Thomas Tiang, Larisa M Haupt, Rod A Lea, Lyn R Griffiths |
Abstract |
The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many diagnostic characteristics in common. It is postulated that migraine symptomatic characteristics might themselves be influenced by MTHFR. Here we analysed the clinical profile, migraine symptoms, triggers and treatments of 267 migraineurs previously genotyped for the MTHFR C677T variant. The chi-square test was used to analyse all potential relationships between genotype and migraine clinical variables. Regression analyses were performed to assess the association of C677T with all migraine clinical variables after adjusting for gender. |
X Demographics
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Unknown | 3 | 100% |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 42 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 18% |
Student > Ph. D. Student | 7 | 16% |
Student > Bachelor | 7 | 16% |
Researcher | 6 | 14% |
Professor > Associate Professor | 6 | 14% |
Other | 7 | 16% |
Unknown | 3 | 7% |
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Medicine and Dentistry | 9 | 20% |
Agricultural and Biological Sciences | 7 | 16% |
Nursing and Health Professions | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Physics and Astronomy | 3 | 7% |
Other | 16 | 36% |
Unknown | 3 | 7% |