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Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning

Overview of attention for article published in Molecular Brain, February 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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1 news outlet
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2 X users

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47 Dimensions

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104 Mendeley
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Title
Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
Published in
Molecular Brain, February 2012
DOI 10.1186/1756-6606-5-6
Pubmed ID
Authors

Giannina Descalzi, Xiang-Yao Li, Tao Chen, Valentina Mercaldo, Kohei Koga, Min Zhuo

Abstract

Although the cortex has been extensively studied in long-term memory storage, less emphasis has been placed on immediate cortical contributions to fear memory formation. AMPA receptor plasticity is strongly implicated in learning and memory, and studies have identified calcium permeable AMPA receptors (CP-AMPARs) as mediators of synaptic strengthening. Trace fear learning engages the anterior cingulate cortex (ACC), but whether plastic events occur within the ACC in response to trace fear learning, and whether GluN2B subunits are required remains unknown. Here we show that the ACC is necessary for trace fear learning, and shows a rapid 20% upregulation of membrane AMPA receptor GluA1 subunits that is evident immediately after conditioning. Inhibition of NMDA receptor GluN2B subunits during training prevented the upregulation, and disrupted trace fear memory retrieval 48 h later. Furthermore, intra-ACC injections of the CP-AMPAR channel antagonist, 1-naphthylacetyl spermine (NASPM) immediately following trace fear conditioning blocked 24 h fear memory retrieval. Accordingly, whole cell patch clamp recordings from c-fos positive and c-fos negative neurons within the ACC in response to trace fear learning revealed an increased sensitivity to NASPM in recently activated neurons that was reversed by reconsolidation update extinction. Our results suggest that trace fear learning is mediated through rapid GluN2B dependent trafficking of CP-AMPARs, and present in vivo evidence that CP-AMPAR activity within the ACC immediately after conditioning is necessary for subsequent memory consolidation processes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
Hong Kong 1 <1%
United Kingdom 1 <1%
Russia 1 <1%
United States 1 <1%
Unknown 99 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 25%
Researcher 20 19%
Student > Master 10 10%
Professor > Associate Professor 8 8%
Professor 7 7%
Other 21 20%
Unknown 12 12%
Readers by discipline Count As %
Neuroscience 32 31%
Agricultural and Biological Sciences 31 30%
Psychology 12 12%
Biochemistry, Genetics and Molecular Biology 5 5%
Medicine and Dentistry 5 5%
Other 8 8%
Unknown 11 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2022.
All research outputs
#2,798,297
of 22,663,150 outputs
Outputs from Molecular Brain
#132
of 1,103 outputs
Outputs of similar age
#23,852
of 247,566 outputs
Outputs of similar age from Molecular Brain
#3
of 14 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,566 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.