Title |
Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions
|
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Published in |
Virology Journal, February 2012
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DOI | 10.1186/1743-422x-9-45 |
Pubmed ID | |
Authors |
Varun Dwivedi, Cordelia Manickam, Basavaraj Binjawadagi, Daniel Linhares, Michael P Murtaugh, Gourapura J Renukaradhya |
Abstract |
Porcine reproductive and respiratory syndrome virus (PRRSV) causes chronic, economically devastating disease in pigs of all ages. Frequent mutations in the viral genome result in viruses with immune escape mutants. Irrespective of regular vaccination, control of PRRSV remains a challenge to swine farmers. In PRRSV-infected pigs, innate cytokine IFN-α is inhibited and the adaptive arm of the immunity is delayed. To elucidate both cellular and innate cytokine responses at very early stages of PRRSV infection, seven weeks old pigs maintained on a commercial pig farm were infected and analyzed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 2 | 2% |
United States | 2 | 2% |
Mexico | 1 | 1% |
Unknown | 77 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 17% |
Student > Ph. D. Student | 13 | 16% |
Researcher | 9 | 11% |
Student > Doctoral Student | 7 | 9% |
Student > Postgraduate | 7 | 9% |
Other | 17 | 21% |
Unknown | 15 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 34% |
Veterinary Science and Veterinary Medicine | 16 | 20% |
Medicine and Dentistry | 8 | 10% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Nursing and Health Professions | 2 | 2% |
Other | 7 | 9% |
Unknown | 16 | 20% |