Title |
HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know
|
---|---|
Published in |
Pediatric Rheumatology, March 2016
|
DOI | 10.1186/s12969-016-0072-x |
Pubmed ID | |
Authors |
Ingrid Herta Rotstein Grein, Noortje Groot, Marcela Ignacchiti Lacerda, Nico Wulffraat, Gecilmara Pileggi |
Abstract |
Patients with Systemic Lupus Erythematosus (SLE) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients. Most non-live vaccines are immunogenic and safe in patients with SLE, even if antibody titres are frequently lower than those of healthy controls. Human papillomavirus (HPV) infections are more prevalent in SLE patients when compared to the healthy population. Low-risk types of this virus cause anogenital warts, while high risk types are strongly related to pre-malignant cervical abnormalities and cervical cancer. HPV vaccines have been developed to prevent these conditions. Although little is known about HPV vaccination in SLE, few studies in patients with autoimmune rheumatic diseases (AIRDs) have shown that HPV vaccines are safe, and capable to induce an immunogenic response in this group of patients. To date, available data suggest that HPV vaccines can be given safely to SLE patients. Given the increased incidence of cervical abnormalities due to HPV in SLE patients, this vaccination should be encouraged. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Singapore | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 14% |
Student > Master | 10 | 14% |
Student > Ph. D. Student | 9 | 13% |
Student > Postgraduate | 7 | 10% |
Other | 6 | 9% |
Other | 15 | 22% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 57% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Agricultural and Biological Sciences | 1 | 1% |
Other | 2 | 3% |
Unknown | 15 | 22% |